This week 2 of using the 2 oz Paracleanse Tincture and D-tox Binder capsules. I take them once a day, increasing the tincture at little intervals, while drinking plenty water throughout the day. It is not harsh and doesn't have that laxative effect, like cramping, etc. The same with the binder capsules, no cramping, bloating, etc. Does the job without being harsh. I would recommend these products to family and friends. Kimball Botanicals products are good and trustworthy.